Abu-Kishk I, Zohar E, Berkovitch M, Kozer E, Seguier-Lipszyc E, Klin B, Elizur A. Factors associated with empyema in children with community acquired pneumonia. Minerva Pediatr. 2015 Dec;67(6):473-9. Epub 2014 Jul 30. PMID: 25075454.

Minerva Pediatr. 2015 Dec;67(6):473-9. Epub 2014 Jul 30.

Factors associated with empyema in children with community acquired pneumonia.

Abu-Kishk I(1), Zohar E, Berkovitch M, Kozer E, Seguier-Lipszyc E, Klin B, Elizur A.

Author information:
(1)Pediatric Division, Assaf Harofeh Medical Center, Zerifin, Affiliated to the Sackler Faculty of Medicine, Tel‑Aviv University, Tel‑Aviv, Israel - abukishki@gmail.com.

AIM: Empyema is a potential complication of community acquired pneumonia but factors predicting this complication are lacking.

METHODS: A retrospective study of all previously healthy pediatric patients admitted between January 2007 and July 2009 with CAP. Patients with non-lobar pneumonia, RSV bronchiolitis, underlying chronic disease, or hospital-acquired pneumonia were excluded. Preadmission, clinical characteristics on admission, and outcome were compared between patients with and without empyema. Management strategies in patients with empyema were also compared.

RESULTS: Overall 356 patients were included. Median age was 3.8 ± 3.54 years and 60.7% were males. A total of 43 patients (12%) were diagnosed with empyema. The development of empyema was independently associated, on multivariate analysis, with older age, female gender and antibiotic therapy prior to admission, and with dyspnea, thrombocytopenia and involvement of more than one lobe on chest radiograph on admission. Patients who developed empyema had a longer and more complicated course. Hypoxemia on admission was significantly less frequent in patients with empyema who were treated with antibiotic therapy alone, compared to those treated with chest tube or video-assisted thoracoscopic surgery.

CONCLUSION: Early identification of dyspnea and thrombocytopenia in patients with community acquired pneumonia could alert physicians on the potential development of empyema. Antibiotic therapy alone may be sufficient in patients with empyema who are mildly hypoxemic on admission.

PMID: 25075454  [PubMed - in process]

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