Eisen A, Lev E, Iakobishvilli Z, Porter A, Brosh D, Hasdai D, Mager A. Low plasma vitamin D levels and muscle-related adverse effects in statin users. Isr Med Assoc J. 2014 Jan;16(1):42-5. PMID: 24575504.

Isr Med Assoc J. 2014 Jan;16(1):42-5.

Low plasma vitamin D levels and muscle-related adverse effects in statin users.

Eisen A(1), Lev E(1), Iakobishvilli Z(1), Porter A(1), Brosh D(1), Hasdai D(1), Mager A(1).

Author information:
(1)Department of Cardiology, Rabin Medical Center (Beilinson Campus), Petah Tikva, Israel.

BACKGROUND: Treatment with HMG-CoA reductase inhibitors (statins) is often complicated by muscle-related adverse effects (MAEs). Studies of the association between low plasma vitamin D levels and MAEs have yielded conflicting results.

OBJECTIVES: To determine if low plasma vitamin D level is a risk factorfor MAEs in statin users.

METHODS: Plasma levels of 25(OH) vitamin D were measured as part of the routine evaluation of unselected statin-treated patients attending the coronary and lipid clinics at our hospital during the period 2007-2010. Medical data on muscle complaints and statin use were retrieved from the medical files. Creatine kinase (CK) levels were derived from the hospital laboratory database.

RESULTS: The sample included 272 patients (141 men) aged 33-89 years. Mean vitamin D level was 48.04 nmol/L. Levels were higher in men (51.0 +/- 20.5 versus 44.7 +/- 18.9 nmol/L, P = 0.001) and were unaffected by age. MAEs were observed in 106 patients (39%): myalgia in 95 (35%) and CK elevation in 20 (7%); 9 patients (3%) had both. There was no difference in plasma vitamin D levels between patients with and without myalgia (46.3 +/- 17.7 versus 48.9 +/- 21.0 nmol/L, P = 0.31), with and without CK elevation (50.2 +/- 14.6 versus 47.8 +/-20.3 nmol/L, P = 0.60), or with or without any MAE (50.4 +/- 15.0 versus 47.8 +/-10.2 nmol/L, P = 0.27). These findings were consistent when analyzed by patient gender and presence/absence of coronary artery disease, and when using a lower vitamin D cutoff (< 25 nmol/L).

CONCLUSIONS: There is apparently no relationship between plasma vitamin D level and risk of MAEs in statin users.

PMID: 24575504  [PubMed - indexed for MEDLINE]

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