Boltin D, Zvidi I, Steinmetz A, Bernstine H, Groshar D, Nardi Y, Boaz M, Niv Y, Dickman R. Vomiting and dysphagia predict delayed gastric emptying in diabetic and nondiabetic subjects. J Diabetes Res. 2014;2014:294032. Epub 2014 May 11. PMID: 24949485.

J Diabetes Res. 2014;2014:294032. doi: 10.1155/2014/294032. Epub 2014 May 11.

Vomiting and dysphagia predict delayed gastric emptying in diabetic and nondiabetic subjects.

Boltin D(1), Zvidi I(1), Steinmetz A(2), Bernstine H(2), Groshar D(2), Nardi Y(3), Boaz M(4), Niv Y(1), Dickman R(1).

Author information:
(1)Department of Gastroenterology, Rabin Medical Center, Beilinson Hospital, 39 Jabotinski Street 49100, Petach Tikva, Israel.
(2)Department of Nuclear Medicine, Rabin Medical Center, Beilinson Hospital, Israel.
(3)Department of Biostatistics, Rabin Medical Center, Beilinson Hospital, Israel.
(4)Epidemiology Unit, Edith Wolfson Medical Center, Holon and the Sackler Faculty of Medicine, Tel Aviv University, Israel.

BACKGROUND: Gastroparesis is a heterogeneous disorder most often idiopathic, diabetic, or postsurgical in nature. The demographic and clinical predictors of gastroparesis in Israeli patients are poorly defined.

METHODS: During the study period we identified all adult patients who were referred to gastric emptying scintigraphy (GES) for the evaluation of dyspeptic symptoms. Of those, 193 patients who were referred to GES from our institution were retrospectively identified (76 (39%) males, mean age 60.2 ± 15.6 years). Subjects were grouped according to gastric half-emptying times (gastric T 1/2). Demographic and clinical data were extracted from electronic medical records or by a phone interview.

KEY RESULTS: Gastric emptying half-times were normal (gastric T 1/2 0-99 min) in 101 patients, abnormal (gastric T 1/2 100-299 min) in 67 patients, and grossly abnormal (gastric T 1/2 ≥ 300 min) in 25 patients. Vomiting and dysphagia, but neither early satiety nor bloating, correlated with delayed gastric emptying. Diabetes was associated with grossly abnormal gastric T 1/2. Idiopathic gastroparesis was associated with a younger age at GES. No correlation was observed between gastric T 1/2 values and gender, smoking, H. pylori infection, HBA1C, or microvascular complication of diabetes.

CONCLUSIONS INFERENCES:Vomiting and dysphagia are predictive of delayed gastric emptying in both diabetic and nondiabetic subjects. Diabetes is associated with more severe gastroparesis.

PMCID: PMC4037617

PMID: 24949485  [PubMed - indexed for MEDLINE]

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