Almoznino G, Zini A, Mizrahi Y, Aframian DJ. Elevated serum IgE in recurrent aphthous stomatitis and associations with disease characteristics. Oral Dis. 2014 May;20(4):386-94. PubMed PMID: 23730959.

Oral Dis. 2014 May;20(4):386-94. doi: 10.1111/odi.12131. Epub 2013 Jun 4.

Elevated serum IgE in recurrent aphthous stomatitis and associations with disease characteristics.

Almoznino G(1), Zini A, Mizrahi Y, Aframian DJ.

Author information:
(1)Department of Oral Medicine, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel; Department of Oral Medicine, Oral and Maxillofacial Center, Medical Corps, Israel Defense Forces, Tel Hashomer, Israel.

OBJECTIVES: To characterize demographic, clinical and serological parameters in recurrent aphthous stomatitis (RAS) patients and analyse their association with serum immunoglobulin E (IgE) levels.

SUBJECTS AND METHODS: Forty-nine patients with RAS responded to a questionnaire that included demographic background, stress status, smoking habits, history and course of RAS episodes. They were also subjected to relevant laboratory tests, including determination of serum IgE levels.

RESULTS: A familial history of RAS was reported by 47.9% of the patients, stress in the previous year by 51.1% and smoking by 18.4%. Non-Caucasian origin, familial history of RAS, stress and smoking were associated with increased severity of RAS episodes. Haematological deficiencies were observed in 18.7% of RAS patients. Average IgE levels were increased and were significantly associated ‎with younger ‎age, ‎≤12 years of schooling, ‎female gender, ‎RAS ‎episode frequency of every ‎2 weeks‎,‎ early onset of RAS episodes and elevated C reactive protein levels.

CONCLUSION: Immunoglobulin E levels may be considered as part of the RAS patient's work-up. Further research is needed to identify biological mechanisms that account for the observed associations.

© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PMID: 23730959  [PubMed - indexed for MEDLINE]

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