Martín-Martos F et al, Riete Investigators.Gender differences in cancer patients with acute venous thromboembolism. Thromb Res. 2015 Feb;135 Suppl 1:S12-5. PubMed PMID: 25903526.
Thromb Res. 2015 Feb;135 Suppl 1:S12-5. doi: 10.1016/S0049-3848(15)50433-7. Epub 2015 Feb 9.
Gender differences in cancer patients with acute venous thromboembolism.
Martín-Martos F(1), Trujillo-Santos J(1), Barrón M(2), Vela J(3), Javier Marchena P(4), Braester A(5), Hij A(6), Hernández-Blasco L(7), Verhamme P(8), Manuel M(9), Riete Investigators.
BACKGROUND: The outcome of cancer patients with acute venous thromboembolism (VTE) may differ according to gender.
METHODS: We used the RIETE database to compare the rate of VTE (pulmonary embolism [PE] or deep vein thrombosis [DVT]) recurrences), major bleeding and mortality during the course of anticoagulation, according to gender.
RESULTS: As of August 2014, 11,055 patients with active cancer were enrolled in RIETE, of whom 5,104 (46%) were women. During the course of anticoagulation (mean: 142 days), 505 patients developed recurrent VTE, 429 bled and 2730 died. Compared with men, women had a significantly lower rate of fatal bleeding (risk ratio [RR]: 0.69; 95% CI: 0.47-0.99) and death (RR: 0.90; 95% CI: 0.83-0.97), and a non-significantly lower rate of PE recurrences (RR 0.83; 95% CI: 0.65-1.06) and major bleeding (RR: 0.89; 95% CI: 0.74-1.08).
CONCLUSIONS: During the course of anticoagulation, cancer women with VTE had a better outcome than men.
© 2015 Elsevier Ltd. All rights reserved.
PMID: 25903526 [PubMed - in process]