Birati EY, Eldar M, Belhassen B. Gender differences in accessory connections location: an Israeli study. J Interv Card Electrophysiol. 2012 Sep;34(3):227-9. doi: 10.1007/s10840-012-9683-4. PubMed PMID: 22580632.

J Interv Card Electrophysiol. 2012 Sep;34(3):227-9. doi: 10.1007/s10840-012-9683-4. Epub 2012 May 13.

Gender differences in accessory connections location: an Israeli study.

Birati EY, Eldar M, Belhassen B.

Department of Cardiology, Tel Aviv Sourasky Medical Center and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. ebirati@hotmail.com

BACKGROUND: Recent studies have shown that the pathogenesis of accessory connections (AC) formation may have a genetic component.

OBJECTIVE: The purpose of the study was to examine whether AC location differs by gender in a large cohort of patients with AC undergoing radiofrequency ablation (RFA) in two Israeli electrophysiology (EP) laboratories.

METHODS: All consecutive patients who underwent RFA of single ACs in Tel Aviv Sourasky Medical Center between 1992 and 2009 (n = 574) as well as the first consecutive 230 patients who underwent RFA in Sheba Medical Center between 1992 and 2001 were included in this study.

RESULTS: The 804 patients in the two centers included 511 males (63.6 %) and 293 (36.4 %) females, mean age 34 + 16 years old. The AC was located in the left free wall, posteroseptal, right free wall, right anteroseptal, and in other areas in 57.8, 22.8, 9.3, 7 and 3.1 % of patients, respectively. The anatomical AC distribution was similar in the two EP laboratories. A right free wall location was more frequent in females (13 %) than in males (7.2 %; p = 0.008). A right anteroseptal location was more frequent in males (8.4 %) than in females (4.4 %) (p = 0.043). The left free wall and posteroseptal locations were similarly encountered in males (58.1 and 23.1 %, respectively) and in females (57.3 and 22.2 %, respectively).

CONCLUSIONS: In our Israeli population, females more commonly have right free wall ACs and males more commonly have right anteroseptal ACs. These findings support the possible role of a genetic component in the pathogenesis of AC formation.

PMID: 22580632  [PubMed - indexed for MEDLINE]

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